The Regulation of Golgi and Centrosome Dynamics in Mammalian Cells – We are interested in how organelles of the pericentriolar region communicate with each other. In mammalian cells, Golgi membranes are positioned in close proximity to the centrosome, the major microtubule organizing center of a cell. This specific localization is only seen during interphase as Golgi membranes are fragmented and dispersed throughout the cytosol during mitosis.
Another organelle that is positioned in this region of an infected cell is the inclusion, a membrane-bound compartment in which the bacterium, Chlamydia, resides and replicates. As an obligatory intracellular parasite, Chlamydia has extensive, but often poorly characterized interactions with its host.Continue Reading →