HomeFacultySteven Gross

Steven Gross

Steven Gross, Ph.D.
Professor

2222 Natural Sciences I
University of California Irvine
Irvine, CA 92697

Tel: (949) 824-3159
Fax:
(949) 824-4709
Email:
sgross@uci.edu
Website:
Lab Homepage

Laser tweezers; Regulation of molecular motors – My research is quite cross-disciplinary. The majority of biological studies have focused on biochemical or genetic understanding of biological processes, however understanding the relevant physical processes is also important. Proteins physically do things, and to understand the biology, we must start to think about proteins as machines, as well as considering their biochemical properties and genetic regulation. We will soon know the Human Genome, we already know the Drosophila and the C. Elegans Genomes, and yet are very far from understanding how proteins work, and how the exquisitely ordered structures we observe in cells, embryos, and developed organisms come about. Cytoskeletal processes such as transport are important in the creation of this order, and my lab is attempting to develop and apply physical tools to quantify transport as it occurs in living cells.

Recent Publications

  • K.P. Bohannon, Y. Jun, S.P. Gross, and G.A. Smith, “Differential protein partitioning within the herpesvirus tegument and envelope underlie a complex and variable virion architecture.”, PNAS, in press, (2013).
  • S. P. Gross, “Come together: group behavior of Dynein motors.”, Dev. Cell. Jan 28; 24(2):117-8. (2013)
  • R.P. Erickson, S.P. Gross+†, and C.C. Yu+†, “Filament-Filament Switching Can Be Regulated by Separation Between Filaments Together with Cargo Motor Number”, PLOS one, 8(2):e54298 (2013).
  • P. Anand*, S. Cermelli*, Z. Li, A. Kassan, M. Bosch, R. Sigua, L. Huang, A.J. Ouellette, A. Pol, M.A Welte, and S.P. Gross, “A novel role for lipid droplets in the organismal antibacterial response”, eLife, November 13 (2012).
  • J. Xu, Z. Shu, S.J. King, and S.P. Gross, “Tuning Multiple Motor Travel Via Single Motor Velocity”, Traffic, March 27, (2012).
  • J. Lee, S. P. Gross, and J. Lee, “Modularity optimization by conformational space annealing”, Phys. Rev. E, 85(5 pt 2) (2012).
  • R. Sigua, S. Tripathy, P. Anand+†, and S.P. Gross+†, “Isolation and Purification of Kinesin from Drosophila Embryos”, J. Vis. Exp. (62), e3501, DOI: 10.3791/3501 (2012).
  • J. Xu, B.J. N. Reddy*, P. Anand,*, Z. Shu,*, S. Cermelli, M.K. Mattson, S.K. Tripathy, M.T. Hoss, N.S. James, S.J. King, L. Huang, L. Bardwell and S.P. Gross+†, “Casein kinase 2 reverses tail-independent inactivation of kinesin-1”, Nature Communications, March 27, (2012). PMID: 22453827
  • M. Bosch, M. Marí, S.P. Gross, J.C. Fernández-Checa, and A. Pol, “Mitochondrial cholesterol: a connection between caveolin and metabolism”, Traffic 12(11) (2011).
  • J. Yi, K. Ori-McKenney, R. McKenney, M. Vershinin, S.P. Gross, and R. B. Vallee, “High Resolution Imaging Reveals Indirect Coordination of Opposite Motors and LIS1 Role in High-load Axonal Transport.”, in press. J. Cell Biol., (2011). PMID: 22006948
  • A. Kunwar, S. Tripathy, J. Xu, M.K. Mattson, P. Anand, R. Sigua, M. Vershinin, R.J. McKenney, C.C. Yu, A. Mogilner+†, and S.P. Gross+†, “Mechanical Stochastic Tug-of-war Models Cannot Explain Bi-directional Lipid droplet Transport” , PNAS (2011). PMID: 22084076
  • R.P. Erickson, Z. Jia, S.P. Gross+† and C.C. Yu+†, “How Molecular Motors are Arranged on a Cargo is Important for Vesicular Transport”, PLOS Computational Biology 7(5) (2011).
  • M. Bosch, M. Marí, A. Herms, A. Fernández, A. Fajardo, A. Kassan, A. Giralt, A. Colell, D.Balgoma, E. Barbero, E. González-Moreno, N. Matias, F. Tebar, J. Balsinde, M. Camps, C. Enrich, S.P. Gross, C. García-Ruiz, E. Pérez-Navarro, J.C. Fernández-Checa, and A. Pol., “Caveolin-1 deficiency causes cholesterol dependent mitochondrial dysfunction and apoptotic susceptibility” , Curr. Biol. 26 (2011).
  • K.M. Ori-McKenney*, J. Xu*, S.P. Gross+†, and R.B. Vallee+†, “A Cytoplasmic Dynein Tail Mutation Impairs Motor Processivity”, Nature Cell Bio., 12(12):1228-34 (2010).
  • J. Xu and S.P. Gross, “Biophysics of dynein in vivo” (invited review), to appear in Dyneins: Structure, Biology and Disease, (Elsevier), Editor Stephen M. King (2011).
  • G. T. Shubeita and S. P. Gross, “”Intracellular transport: relating single-molecule properties to in vivo function” (invited review), to appear in Comprehensive Biophysics, (Elsevier), Editor Ed Egelman (2011).
  • R. J. McKenney*, M. Vershinin*, A. Kunwar, R. B. Vallee+† and S. P. Gross+†, “LIS1 and NudE Induce a Persistent Dynein Force-Producing State”, Cell 141: 304–314, (2010).
  • K.H. Bremner, J. Scherer, J. Yi, M. Vershinin, S.P. Gross, and R.B. Vallee, “Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit”. Cell Host Microbe. 6(6):523-35. (2009)
  • M. Ingelmo-Torres, E. González-Moreno, A. Kassan, M. Hanzal-Bayer, F. Tebar, A. Herms, T. Grewal, J.F. Hancock, C. Enrich, M. Bosch, S.P. Gross, R.G. Parton and A. Pol, “Hydrophobic and Basic Domains Target Proteins to Lipid Droplets”, Traffic 10(12):1785-801 (2009)
  • R. Mallik and S.P.Gross, “Intracellular Transport: How Do Motors Work Together?” (review), Curr Biol.19(10), (2009).
  • F. Ziebert, M. Vershinin, S.P. Gross, and I.S. Aranson, “Collective alignment of polar filaments by molecular motors”, Eur Phys J E Soft Matter. (2009)
  • K. S. Larsen, J. Xu, S. Cermelli, Z. Shu, and S.P. Gross, “BicaudalD actively regulates microtubule motor activity in lipid droplet transport.” PLOS One 3(11):e3763. (2008).
  • Shubeita GT, Tran SL, Xu J, Vershinin M, Cermelli S, Cotton SL, Welte MA, Gross SP. (2008) Consequences of motor copy number on the intracellular transport of kinesin-1-driven lipid droplets. Cell., 135(6):1098-107
  • Larsen KS, Xu J, Cermelli S, Shu Z, Gross SP. (2008) BicaudalD actively regulates microtubule motor activity in lipid droplet transport. PLoS One., 3(11):e3763.
  • Kunwar A, Vershinin M, Xu J, Gross SP. (2008) Stepping, strain gating, and an unexpected force-velocity curve for multiple-motor-based transport. Curr Biol., 18(16):1173-83.
  • Vershinin M, Xu J, Razafsky DS, King SJ,Gross SP (2008) Tuning microtubule-based transport through filamentous MAPs: the problem of dynein. Traffic., 9(6):882-92.
  • Carter BC, Vershinin M, Gross SP. (2008) A comparison of step-detection methods: how well can you do? Biophys J., 94(1):306-19.
  • Gross SP, Vershinin M, Shubeita GT. (2007) Cargo transport: two motors are sometimes better than one. Curr Biol.,17(12):R478-86. Review.
  • Gross SP. (2007) Molecular motors: a tale of two filaments. Curr Biol. 17(8):R277-80
  • Petrov DY, Mallik R, Shubeita GT, Vershinin M, Gross SP, Yu CC. (2007) Studying molecular motor-based cargo transport: what is real and what is noise? Biophys J., 92(8):2953-63.
  • Martinez JE, Vershinin MD, Shubeita GT, Gross SP. (2007) On the use of in vivo cargo velocity as a biophysical marker. Biochem Biophys Res Commun. 353(3):835-40.
  • Vershinin M, Carter BC, Razafsky DS, King SJ, Gross SP. (2007) Multiple-motor based transport and its regulation by Tau. Proc Natl Acad Sci U S A. 104(1):87-92.

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