Professor Lawrence J. Marsh, Developmental and Cell Biology, in collaboration with members of Dr. C-K Shen’s lab in Academica Sinica, Taiwan, found that the distribution of mutant Huntingtin protein (HTT) in the brains of mice changes in concert with changing pathology and progressive loss of motor control. One consequence of the changing redistribution of the protein is disruption of the nuclear envelope and reactivation of the cell cycle, which leads to death of the neuron. Read more.