- This event has passed.
Event Navigation
Dr. Dae Seok Eom
Assistant Professor, Department of Developmental Cell Biology
University of California, Irvine
“Airineme-mediated intercellular communication in zebrafish skin”
Abstract:
Cell-to-cell signaling is a fundamental process in living organisms, and its misregulation can lead to various diseases and cancers. Consequently, understanding its underlying mechanisms has been a central topic in biology and medicine for decades. Recent advancements have identified previously unappreciated signaling modalities, one of which is airinemes. Airinemes are long cellular protrusions that extend and target pigment cells, playing a critical role in pigment pattern development in zebrafish. They deliver Delta ligands from yellow pigment cells to dark melanophores, where they activate Notch signaling in a target-specific manner. Interestingly, skin-resident macrophages are essential for airineme signaling. The complex interplay between airineme-extending and airineme-receiving cells, as well as macrophages, is a unique feature of this signaling mechanism.
Since establishing my lab at UCI in 2018, current and former lab members have focused on elucidating the underlying cellular and molecular mechanisms of airineme-mediated signaling and other signaling cellular protrusions. In this talk, I will present the discoveries we have made over the past six years and outline future directions for our research.
For more info on Dr. Eom's work:
https://eomlaboratory.com/
View event flyer here.
Seminar held in person only.