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Dr. Heather Lawson

Assistant Professor of Genetics
Washington University in St Louis
School of Medicine

“Parent-of-Origin Effects Propagate through Networks to Shape Metabolic Traits”

Abstract:

Parent-of-origin effects are unexpectedly common in complex traits, including metabolic and neurological traits. Parent-of-origin effects can be modified by the environment, but the architecture of these gene-by-environmental effects on phenotypes remains to be unraveled. Previously, quantitative trait loci (QTL) showing context-specific parent-of-origin effects on metabolic traits were mapped in the F16 generation of an advanced intercross between LG/J and SM/J inbred mice. However, these QTL were not enriched for known imprinted genes, suggesting another mechanism is needed to explain these parent-of-origin effects phenomena. We propose that non-imprinted genes can generate complex parent-of-origin effects on metabolic traits through interactions with imprinted genes. Here, we employ data from mouse populations at different levels of intercrossing (F0, F1, F2, F16) of the LG/J and SM/J inbred mouse lines to test this hypothesis. Using multiple populations and incorporating genetic, genomic, and physiological data, we leverage orthogonal evidence to identify networks of genes through which parent-of-origin effects propagate.

 

 

For more info about Dr. Lawson's research:

https://profiles.wustl.edu/en/persons/heather-lawson


Seminar will be held in person only.

Details

Date:
May 30
Time:
11:00 am - 12:00 pm

Venue

4201 Natural Sciences II
4201 Natural Sciences II
Irvine, CA 92697 United States

Organizer

Mayra Rubio
Phone:
949-824-1969
Email:
mrubio3@uci.edu

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