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DTSTART;TZID=America/Los_Angeles:20261112T110000
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DTSTAMP:20261109T194138Z
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SUMMARY:DCB Seminar Series: Jeffrey Kim
DESCRIPTION:Jeffrey Kim\, Department of Clinical Pharmacy PracticeSchool of Pharmacy and Pharmaceutical SciencesUniversity  of California\, Irvine \n\n\n\n“Intercellular Signaling and Dopaminergic Neurodegeneration in Parkinson’s Disease” 
URL:https://devcell.bio.uci.edu/calendar/dcb-seminar-series-jeffrey-kim/
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DTSTART;TZID=America/Los_Angeles:20261119T110000
DTEND;TZID=America/Los_Angeles:20261119T120000
DTSTAMP:20261109T194451Z
CREATED:20260909T184200Z
LAST-MODIFIED:20261109T194451Z
UID:8251-1795086000-1795089600@devcell.bio.uci.edu
SUMMARY:DCB Seminar Series: Andrew Stergachis 
DESCRIPTION:Andrew Stergachis Associate Professor\, Department of Molecular and Medical GeneticsUniversity of Washington \n\n\n\n\n\n\n\n\n\n\n\n“The diploid chromatin epigenome: what’s the difference?”Advances in long-read sequencing and genome assembly now enable the routine generation of near-complete diploid telomere-to-telomere (T2T) genomes. As the genetic landscape of these diploid T2T genomes comes into focus\, the next major challenge is to understand the functional differences between the two haploid genomes that comprise an individual’s diploid genome. I will present recent advances from our team in long-read single-molecule epigenetic mapping that enable resolution of the complete diploid chromatin epigenome at both the single-molecule (Fiber-seq) and single-cell (DAF-seq) levels. Using data generated through the Somatic Mosaicism across Human Tissues (SMaHT) Network\, the Human Pangenome Reference Consortium (HPRC)\, the Undiagnosed Diseases Network (UDN)\, and the GREGoR Consortium\, I will demonstrate how germline genetic variation\, somatic epimutations\, and stochastic gene regulatory processes shape the diploid chromatin epigenome. Collectively\, these studies provide a new framework for measuring and conceptualizing function within the diploid T2T genome.
URL:https://devcell.bio.uci.edu/calendar/dcb-seminar-series-andrew-stergachis/
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DTSTART;TZID=America/Los_Angeles:20261210T110000
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DTSTAMP:20261109T194557Z
CREATED:20260909T184400Z
LAST-MODIFIED:20261109T194557Z
UID:8253-1796900400-1796904000@devcell.bio.uci.edu
SUMMARY:DCB Seminar Series: Mehboob Hussain
DESCRIPTION:Mehboob Hussain\, Professor\, Division of Endocrinology\, MedicineUniversity of California\, Irvine
URL:https://devcell.bio.uci.edu/calendar/dcb-seminar-series-mehboob-hussain/
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