Irvine, CA 92697-2300
Tel: (949) 824-6677
Fax: (949) 824-4709
jlmarsh@uci.edu
Tel: (949) 824-3226
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RESEARCH INTEREST: Developmental genetics
The processes of development are fundamental to life and health. They require the coordinated effort of many cells in time and space to create, maintain and repair our tissues and organs. Coordination is achieved by cells signaling and responding using short range, paracrine ligand signals (often known as growth factors, oncogenes, cytokines etc) and changing the genes that are expressed in response to these signals. Uncovering the molecular, the biochemical and the genetic mechanisms underlying these critical developmental events would allow us to understand birth defects and the molecular genetic origin of many cancers. It would also provide a basis for 'developmental engineering' namely, the directed manipulation of tissue growth and patterning to regenerate tissues damaged by disease, wounding or surgery.