EVA LEE , Ph.D. Professor Ph.D., University of California, Berkeley, 1984 122 Sprague Hall Tel: (949) 824-9770 Fax: (949) 824- 9767 elee@uci.edu LEE LAB 140 Sprague Hall Tel: (949) 824-9770 (Profile)

RESEARCH INTEREST: Cell cycle and molecular genetics studies of breast c ancer

Research objective in the Lee laboratory is the understanding of molecular events underlying tumorigenesis. Loss of genome stability is a hallmark of tumor cells that is believed to be important in tumor progression and cancer therapeutic response. Deregulated cell cycle control, failure of cell cycle checkpoint activation, and repair of DNA damage all contribute to loss of genome stability. Study of familial clustered cancers and hereditary cancers in the past two decades has facilitated the identification of tumor suppressor genes whose mutation results in cancer predisposition. Many of these tumor suppressor proteins are involved in these cellular processes.