Personal Data

Place of Birth: Si-An, China

Citizenship: U.S.A.

Marital Status: Married; two children

Education

B.S. in Biology National Taiwan University, 1966

Ph.D. in Biology University of California, Los Angeles, 1971

Academic Appointments

Research and Teaching Assistants, Department of Biology, University of California, Los Angeles, 1967 to 1971.

National Institutes of Health Postdoctoral Fellow and Research Pharmacologist, Departments of Pharmacology and Biochemistry and Biophysics, University of California, San Francisco, 1971 to 1974.

Associate Research Scientist, Department of Chemistry, Johns Hopkins University, 1974 to 1977.

Associate Research Scientist, Department of Biophysics, Johns Hopkins University, 1977 to 1978.

Research Scientist, Department of Biophysics, Johns Hopkins University, 1978 to 1997.

Lecturer, Department of Biophysics, Johns Hopkins University, 1995 to 1997.

Associate Adjunct Professor, University of California, Irvine, 1997 to present.

Other Positions and Awards

Special Aging Research Award from the National Institute on Aging, 1978-1981.

Elected member, American Society of Biological Chemists, 1982 to present.

Principal Investigator of NIH Research Grant, “The Role of Cytoskeletal Proteins in Erythrocyte Aging”, 1981-1984.

Visiting Director, Cell Biology Laboratory, Institute of Biomedical Sciences, Academia Sinica, Taiwan, 1988.

Co-Principal Investigator (P.I., Shin Lin) of NIH Research Grant, “Cytochalasin and Proteins that Affect Ends of F-Actin”, 1996-2002.

Teaching Experiences

Organized and taught "Biophysical Techniques", a laboratory course for undergraduate biophysics majors, Johns Hopkins University, 1995-1997

Participated in teaching Bio. Sci 144B (Cell Biology), University of California, Irvine, 1999-present

Participated in teaching Bio. Sci 231B (Cell Biology), University of California, Irvine,

2000-present

Taught Bio Sci 107 (Structure and Function of the Cell), University of California, Irvine,

2003

"Summer Corporate Research Internship Training", an intensive laboratory training course to prepare undergraduates for summer internships sponsored by local corporations, University of California, Irvine, 1999-present

Publications

1. Nobel, P. S., Chang, D. T., Wang, C. T., Smith, S. S., and Barcus, D. E. (1969). Initial ATP Formation, NADP⁺ Reduction, CO₂ Fixation, and Chloroplast Flattening Upon Illuminating Pea Leaves. Pl. Physiol. 44: 655-661.

2. Lin, D. C. and Nobel, P. S. (1971). Control of Photosynthesis by Mg⁺⁺. Arch. Biochem. Biophys. 145: 622-632.

3. Lin, D. C. (1971). Light-Induced Chloroplast Flattening and Changes in Magnesium Levels as Controls of Photosynthetic Efficiency in Pisum sativum. Doctoral Dissertation, University of California, Los Angeles.

4. Kun, E., Lee, N. M., Lin, D. C., Wiedemann, K., Johnson, L., and Dummel, R. J. (1972). Extramitochondrial Regulation of Mitochondrial Energy-coupled Processed by a Cytoplasmic Factor. In “The Molecular Basis of Electron Transfer”, 4: 119-132.

5. Lin, D. C. and Kun, E. (1973). Mode of Action of the Antobiotic X-537A on Mitochondrial Glutamate Oxidation. Biochem. Biophys. Res. Commun. 50: 820-825.

6. Lin, D. C. and Kun, E. (1973). Inhibition of the Oxidation of Glutamate and Isocitrate in Liver Mitochondria at a Specific NADP⁺-Reducing Site. Proc. Natl. Acad. Sci. 70: 3450-3453.

7. Lin, S., Lin, D. C., Spudich, J. A., and Kun, E. (1973). Inhibition of Mitochondrial Contraction by Cytochalasin B. FEBS Letters. 37: 241-243.

8. Gaffney, B. J. and Lin, D. C. (1976). Spin Label Measurements of Membrane-Bound Enzymes. In “the Enzymes of Biological Membranes”, ed. Martonosi, A., Plenum Press, pp 71-90.

9. Gaffney, B. J. and Lin, D. C. (1977). Biophysical Techniques for Measuring Physical Properties of Lipids in Membranes. In “Immunobiology of Gametes”, Edidin, M., and Johnson, M. H., eds., Cambridge University Press, pp. 31-40.

10. Lin, S., Lin, D. C., and Flanagan, M. D. (1978). Specificity of the Effects of Cytochalasin B on Transport and Motile Processes. Proc. Natl. Acad. Sci. 75: 329-333.

11. Lin, D. C. and Lin S. (1978). High-Affinity Binding of [³H]Dihydrocytochalasin B to Peripheral Membrane Proteins Involved in the Control of Cell Shape in the Human Red Cell. J. Biol. Chem. 253:1415-1419.

12. Lin, D. C. and Lin, S. (1979). Actin Polymerization Induced by a Motility-related High-Affinity Cytochalasin binding Complex from Human Erythrocyte Membrane. Proc. Natl. Acad. Sci. 76: 2345-2349.

13. Lin, D. C., Tobin, K., Grumet, M. G., and Lin, S. (1980). Cytochalasins Inhibit Nuclei-Induced Actin Polymerization by Blocking Filament Elongation. J. Cell Biol. 84: 455-460.

14. Lin, D. C. and Lin S. (1980). A Rapid Assay for Actin-Associated High-Affinity Cytochalasin Binding Sites Based on Isoelectric Precipitation of Soluble Proteins. Anal. Biochem. 103: 316-322.

15. Gaffney, B. J., Drachman, D. B., Lin, D. C. and Tennekoon, G. (1980). Spin-Label Studies of Erythrocytes in Myotonic Dystrophy: No Increase in Membrane Fluididty. Neurology 30: 272-276.

16. Lin, D. C. (1980). Spectrin-4.1-Actin Complex of the Human Eruthrocyte. Molecular Basis of Its Ability to Bind Cytochalasin with High-Affinity and to Accelerate Actin Polymerization in vitro. J. Supramol. Strut. 15: 129-138.

17. Lin, D. C. (1981). Studies on Human Erythrocyte Spectrin-4.1-Actin Complex with the use of Cytochalasins. In ”Erythrocyte Membrane: Recent Clinical and Experimental Advances”. Kruckeberg, W. C., Eaton, J. W., and Brewer, G. J., eds., Alan Liss, New York, pp. 117-136.

18. Lin, S., Wilkins, J. A., Cribbs, D. H., Grumet, M. G., and Lin, D. C. (1981). Proteins and Complexes that Affect Actin Filament Assembly and Interactions. Cold Spring Harbor Symp. Quan. Biol. 46: 625-632.

19. Lin, S., Cribbs, D. H., Wilkins, J. A., Casella, J. F., Margargal, W. W., and Lin, D. C. (1982). The Capactins, A Class of Proteins that Cap the Ends of Actin Filaments. Phil. Trans. R. Soc. Lond. 299: 263-273.

20. Lin, D. C., Flanagan, M. D., and Lin, S. (1983). Complexes Containing Actin and Spectrin from Erythrocytes and Brain. Cell Motil. 3: 375-382.

21. Lin, D. C., Tobin, K. D., and Cribbs, D. H. (1984). On the Mechanism for Inactivation of Cytochalasin binding Activity Associated with F-Actin and Spectrin-4.1-Actin Complex by Sulfhydryl Reagents. Biochem. Biophys. Res. Commun. 122: 244-251.

22. Lin, S., Lees, A., Risinger, M. A., Cribbs, D. H., Wilkins, J. A., and Lin, D. C. (1985). Effects of Several Actin binding Proteins on Nucleation, elongation, and Depolymerization of Actin Filaments in vitro. In “Cell Motility: Mechanism and Regulation”, Ishikawa, H., Sato, H., and Hatano, S. Eds., Alan Liss, New York, pp. 189-200.

23. Flanagan, M. D., Lin, D. C., and Lin, S. (1986). Specific Association of Brain Spectrin, Erythrocyte Band 4.1, and Actin in vitro. In “membrane Skeleton and Cytoskeletal-Membrane Associations”, Bennett, V., Cohen, C. M., Lux, S. E., and Palek, J. eds., Alan Liss, New York, pp.243-252.

24. Lin, S., Risinger, M.A., Mullman, T. J., Tseng, J., and Lin, D. C. (1987). Effects of Neoplastic Transformation on the Activity and Cellular Localization of Actin Regulator Proteins in Non-muscle Cells. In “Proceedings of Actin ’87: Informal International Meetings on the Biology of a Ubiquitous Protein. Monza, Italy, pp.99-116.

25. Lai, M. L., Lin, C. Y., Liu, C. H.-L., Ho, H. J., Wang, M. E., Chen, L.-B., Chen, W.-T., Chien, S., Ip, W., Lin, D. C., Lin, J. J.-C., Sun, T. –T., Wang, E., Wang, J. L., Wang, Y.-L., Wu, C.-W., Wu, R., and Lin, S. (1990). Monoclonal antibodies against Nuclear Antigens Associated with Proliferation and Differentiation of Bovine Esophageal Epithelium. In “Structure and Dynamics of the Nucleus”, Wang, E., Wang, J.L., Chien, S., Cheung, W.-Y., and Wu, C.-W., eds., Academic Press, New York, pp.123-138.

26. Tang, T. K., Hong, T. M., Lin, C. Y., Lai, M. L., Liu, C. H., Lo, H. J., Wang, M. E., Chen, L.-B., Chen, W.-T., Ip, W., Lin, D. C., Lin, S., Sun, T. T., Wang, E., Wang J. L., Wu, R., Wu, c. W., and Chien, S. (1993). Nuclear Proteins of the Bovine Esophageal Epithelium. I. Monoclonal Antibody W2 Specifically Reacts with Condensed Nuclei of Differentiated Superficial Cells. J. Cell Sci. 104: 237-247.

27. Chuang, J. Z., Lin, D. C., and Lin, S. (1995). Molecular Cloning, Expression, and Mapping of the High-Affinity Actin-Capping Domain of Chicken Cardiac Tensin. J. Cell Biol. 128: 1095-1109.

28. Lin, D. C., Apgar, J. F., Mahlow, W. J., and Lin, S. (1997). Fluorescence localization of Tensin at Cell-Substrate Contacts in Living Fibroblasts. Cell Vision 4: 181-182.

29. Shin Lin and Diane C. Lin (1999). Tensin. In "Guidebook to the Cytoskeletal and Motor Proteins" pp145-147, T. Kreis and R. Vale eds, Oxford University Press, Oxford.

30. Roumen Pankov, Edna Cukierman, Ben-Zion Katz, Kazue Matsumoto, Diane C. Lin, Shin Lin, Cornelia Hahn, and Kenneth M. Yamada. (2000). Integrin dynamics and Matrix Assembly: Tensin-dependent Translocation of a₅b₁ Integrins Drives Early Fibronectin Fibrillogenesis. J. Cell Biol. 148(5): 1075-90.

31. Zamir, E; Katz, M; Posen, Y; Erez, N; Yamada, KM; Katz, BZ; Lin, S; Lin, DC; Bershadsky, A; Kam, Z; Geiger, B. (2000) Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts. Nature Cell Biology 2(4): 191-6.

32. Katz, BZ; Zohar, M; Teramoto, H; Matsumoto, K; Gutkind, JS; Lin, DC; Lin, S; Yamada, KM. (2000) Tensin can induce JNK and p38 activation. Biochemical and Biophysical Research Communications 272(3): 717-20.

33. Lin, Diane C., Don, Bronson, Piro, Maria C., and Lin, Shin. The Inhibition of Tensin SH2 Domain Binding to Phosphotyrosine by Actin. Manuscript in preparation.

34. Lin, Diane C., Don, Bronson, and Lin, Shin. Phosphoprotein Induced by Cytochalasin D Treatment is Specific Target for Tensin SH2 Domain. Manuscript in preparation.

35. Lin, Diane C. and Lin, Shin. Identification of Two Tensin Binding Sites in Vinculin And Their Possible Regulatory Roles. Manuscript in preparation.