• Conserved signaling pathways controlling growth and development in yeast and mammalian cells.
• Mechanisms of specificity in signal transduction, especially protein kinase signaling.
• Regulation of mitogen-activated protein kinase (MAPK) cascades in yeast and mammalian cells.
• Protein-protein interactions and their role in signaling.

Signal transduction networks are a crucial part of the circuitry by which a cell regulates and coordinates its growth and developmental program, and its response to the external environment. Faulty or malfunctioning signaling pathways lie at the heart of the molecular pathology of many diseases, including cancer. The signaling components we study have been highly conserved through evolution, and are thus of great importance to basic biology, as well as medicine