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Carrie Baker Brachmann Assistant Professor Ph.D., The Johns Hopkins University School of Medicine, 1997 Office: 2214 Natural Sciences
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Apoptosis is an essential process for metazoan development; developing tissues such as the hand are sculpted by the removal of unwanted cells through apoptosis and diseased or damaged cells in adult tissues are eliminated by apoptosis. Despite this fundamental role in tissue development and homeostasis, apoptosis, or the lack thereof, can be extremely deleterious. For instance, inappropriate apoptosis contributes to many neurodegenerative diseases, whereas resistance to apoptosis is a necessary prerequisite for cancer. My laboratory is using Drosophila as a model organism to address issues that are central to our understanding of apoptosis. The apoptotic machinery, inherent to each cell, is kept in a poised but inactive state. We are interested in how this intrinsic machinery is regulated in the developing organism, in response to both developmental cues and cellular damage. Research in the Brachmann
Lab: Select Research Publications: Brachmann, C.B. and Cagan, R.L. (in press). Patterning the Fly Eye: the Role of Apoptosis, [Review] Trends in Genetics. Gorski, S.M., Brachmann, C.B., Tanenbaum, S.B., Cagan R.L. Delta and Notch promote correct localization of IrreC-rst. Cell Death and Diff. 7, 1011-1013. Spencer, S., Brachmann, C.B., Cagan, R.L. (2000). “Drosophila Retinal Patterning”, [Review] Encyclopedia of Life Sciences. www.els.net Macmillan Publishers, Ltd., England. Brachmann, C.B., Jassim, O.W., Wachsmuth, B.D., Cagan, R.L. (2000). The Drosophila Bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation. Curr Biol. 10, 547-550. Brachmann, C.B., Davies, A., Caputo, E., Cost, G., Li, J., Hieter, P., Boeke, J.D. (1998). Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains for PCR-mediated gene disruption and other applications. Yeast 14, 115-132. Brachmann, C.B., Boeke, J.D. (1996). Mapping the multimerization domains of the GAG protein of the yeast Ty1 retrotransposon. J. of Virology 71, 812-817. Brachmann, C.B., Sherman, J.M., Devine, S.E., Cameron, E.E. Pillus, L., Boeke, J.D. (1995). The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes and Development 9(23), 2888-2902. |
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